QUESTION   Do I have to do anything to my macOS settings to allow Workplace to function properly?

ANSWER  In order for Workplace for Mac (v10 or later) to operate properly on macOS, you must Allow Datto to load necessary software on macOS 13 (Ventura) or later:.

If you have a metered plan and are using the backup feature on macOS Mojave or later, you must also Allow full disk access:.

Allow full disk access: